Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Figure 1
Changes in cerebral gray matter volumes in frontal cortices as demonstrated by voxel-based morphometry.
Voxelwise paired t test between baseline and 6 months for ADT (patients who received 6 months of androgen deprivation therapy) and Control (patients who did not receive any hormonal therapy) group, at p<0.001, uncorrected. The difference in gray matter volume, as reflected by a map of T values (color bar), is shown here on a structural brain image in axial sections, from z = -26 to z = +62, with adjacent sections 4 mm apart. Warm color: baseline >6 months; Cool color: 6 months>baseline. Neurological orientation: Right (R) = right. ADT but not control patients showed decreased gray matter volume in the primary motor cortex (PMC), frontopolar cortex (FPC), and dorsolateral prefrontal cortex (DLPFC).