Considerations for Subgroups and Phenocopies in Complex Disease Genetics
Figure 2
Allele frequency alterations due to the presence of a subgroup.
The difference in allele frequencies for a SNP considered classically (top) and as a complex disorder with subgroups (below). In the example, a hypothetical subgroup denoted Subclass 1 contains allele counts a1 and b1, while the rest of the cases contain allele counts a2 and b2.