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Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data

Figure 7

Distribution of putative embryonic brain lncRNAs and permutated lncRNAs with affected expression upon RNA interference of 226 lncRNAs and 40 regulatory proteins based on a published microarray data.

Microarray probes aligned to putative embryonic brain lncRNAs by comparing genomic coordinates are used to explore the expression alteration of putative lncRNAs by comparing microarray profiles of RNA interference of 226 lncRNAs (and 40 regulatory proteins) and controls. The thresholds of 95th percentile and 5th percentile of ranked overall control expression in control profiles are used to obtain up- and down-regulated lncRNAs, respectively. Up-regulation and Down-regulation of putative lncRNAs are not separately analyzed for putative embryonic brain lncRNAs with altered expression. We observe that the distribution of putative embryonic brain lncRNAs with altered expression by RNA interference is separated from putative embryonic brain lncRNAs with altered expression by control interference by Red dash line.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0071152.g007