SIRT1 is a Direct Coactivator of Thyroid Hormone Receptor β1 with Gene-Specific Actions
Figure 10
A Small Molecule SIRT1 activator and inhibitor regulate expression of TRβ1 target genes.
(A∼C) qPCR analysis performed upon HepG2-TRβ cells treated with 100 µM resveratrol +/−T3. Genes are indicated at top. (D∼F) As for 10A–C, except that cells were treated with 10 mM nicotimamide instead of resveratrol. Data are representative of at least two independent experiments. All values represent the mean ± SD of duplicate samples. *, P < 0.05; **, P < 0.01.