Comparison between Internalizing Anti-HER2 mAbs and Non-Internalizing Anti-CEA mAbs in Alpha-Radioimmunotherapy of Small Volume Peritoneal Carcinomatosis Using 212Pb
Figure 6
Biodistribution of 212Pb-labeled mAbs in nude mice bearing A-431 tumor cell xenografts and injected with (A) 212Pb-35A7 (anti-CEA) or (B) 212Pb-trastuzumab (anti-HER2).
%IA/g (not corrected for decay) was determined in healthy organs and tumors. Four mice were analyzed at each time point.