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Single-Prolonged Stress Induces Endoplasmic Reticulum - Dependent Apoptosis in the Hippocampus in a Rat Model of Post-Traumatic Stress Disorder

Figure 2

TEM images of the hippocampus in the SPS rats.

TEM images of the hippocampus. A: Normal control hippocampal neuron, displaying abundant organelles such as mitochondria, endoplasmic reticulum, and ribosomes. The nucleus is large and round, density of chromatin is uniform, and nucleolus is clear. B: Chromatin margination, in the form of crescent formation in nucleus (arrow), is shown. C: The cells showed some typical structural changes indicative of apoptosis, such as chromatin dissolution and, nuclear envelope breakdown (star). Scale bar = 200 nm (A). Scale bar = 300 nm (B and C).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0069340.g002