Soluble ICAM-5, a Product of Activity Dependent Proteolysis, Increases mEPSC Frequency and Dendritic Expression of GluA1
Figure 3
Phosphorylation of GluA1 at serine-845 is increased by soluble ICAM-5.
Rat hippocampal neurons were unstimulated (control) or treated for 60 min. with 1 µg/ml of soluble ICAM-5 and lysates tested by Western blot for phospho-serine 845 GluA1. A representative blot is shown in (A) while densitometric analysis of blots from 5 experiments using distinct cultures is shown in (B). The mean and standard error for the fold increase is shown, and the fold increase is significant at p < 0.1 (*p= 0.06).