Lead Exposure Induces Telomere Instability in Human Cells
Figure 2
Lead induces Telomere-Induced Foci (TIFs).
Results obtained with B3 cells following 24 h exposure with the indicated Pb(NO3)2 concentrations. A. Representative images obtained following IF-FISH. TIFs (yellow) represent co-localisation of γH2Ax (red) and telomere (green) signals. The upper panel shows a representative image of a single metaphase. The lower panel shows representative images of each type of staining pattern obtained from several metaphases B. Localisation of γH2Ax and telomere staining using IF-FISH. *p<0.05, ** p<0.01. The different combinations of staining are shown in the legend on the right.