Opposite Roles of NMDA Receptors in Relapsing and Primary Progressive Multiple Sclerosis
Figure 1
Effect of SNPs in the GRIN1 and GRIN2B genes on cortical excitability in MS.
Role of A) GRIN1 rs4880213 polymorphism in the regulation of cortical excitability. In subjects carrying the ‘TT’ genotype, SICI was significantly lower than in the other subjects at 2 and 3 ms interstimulus intervals (ISI). No significant effect of B) GRIN2B rs1805247, C) GRIN2B rs7301328 and D) GRIN1rs6293 SNPs was found on SICI/ICF. In the four panels, the x-axis indicates the ISI in ms, the y-axis shows the MEP size elicited by paired-pulse stimulation. * means p<0.05.