Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma
Figure 3
Identification of a SUFUT411M mutation in LO68 cell line.
A, Electropherogram of SUFU gene. Left, the sequencing result of MSTO-211H cell line, showing the wildtype SUFU gene. Right, the sequencing result of LO68 carrying the mutant allele. B, Amino acid sequence alignment of SUFU from various species. Shown in the red box is the T411 residue that is evolutionarily conserved among these different species. Numbers indicate the position of amino acid residue with the start codon (methionine) as number 1.