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Kinetic Proofreading at Single Molecular Level: Aminoacylation of tRNA^Ile and the Role of Water as an Editor

Figure 2

Schematic representation of one of the two kinetic proofreading mechanisms (mechanism I) proposed by Fersht.

Here formation of Val-tRNA^Ile is the rate limiting step (k = 1.2 s⁻¹) and it is followed by rapid hydrolysis of the complex.

doi: https://doi.org/10.1371/journal.pone.0066112.g002