Glutamine Supplementation Alleviates Vasculopathy and Corrects Metabolic Profile in an In Vivo Model of Endothelial Cell Dysfunction
Figure 2
Renal function in mice receiving L-NMMA and treated with L-glutamine.
The graphs summarize results of serum creatinine and albumin:creatinine ratio in the urine of control mice and mice receiving a non-pressor dose of L-NMMA with and without 1, 10, and 30 µg/ml L-glutamine. Note that glutamine alone had no effect on either of these parameters of renal function under control conditions. Mice receiving L-NMMA had a mild elevation in serum creatinine and proteinuria. Those animals which were simultaneously treated with L-glutamine at 10 and 30 µg/ml (but not 1 µg/ml) showed normalization of both parameters of renal function.