IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde–Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope
Figure 4
Sequence analysis and comparison of the IgHV of CLL69C to the highly homologous UL10 Fab.
(A) Nucleotide and deduced amino acid sequence comparison of the UL10 Fab IgHV. Comparison was made with the closest CLL69C IgHV gene sequence. Dots indicate homology and dashes indicate no sequence at that position. (B) Amino acid sequence alignment of the IgHV of CLL69C with the UL10 Fab isolated from an umbilical-cord phage-display Fab library. Complementarity determining regions (CDR) are labeled above the amino acid sequence and indicated in bold.