Discovery of Potential New Gene Variants and Inflammatory Cytokine Associations with Fibromyalgia Syndrome by Whole Exome Sequencing
Figure 2
Cytokine secretion of TLR-ligand-treated monocytes transfected with wild type or mutated C11orf40 gene.
Human monocytes were transfected with empty vector (V),wild type C11orf40 (WT) or the W32X truncated mutant gene (T) and challenged with three TLR ligands, LPS (TLR4), CL075 (TLR7/8), and Pam3CSK (TLR 1/2), followed by measurement of secreted cytokine 24 hrs. later. P values are for comparison to vector control (**, P = 0.005) or WT (##, P = 0.005).