Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria monocytogenes
Figure 1
IFN-I increase host resistance after intragastric infection with Listeria monocytogenes.
C57BL/6N Wt and Ifnar1−/− mice were infected with Lm strain LO28InlA*. A, B. Numbers of bacteria in livers (A) and spleens (B) were determined by CFU assay 72 h after intraperitoneal (i.p.) infection with 1×10∧6 Lm. C, D. Bacterial loads of livers (C) and spleens (D) were examined by CFU assay 72 h after intragastric gavage (i.g.) with 5×10∧9 Lm. Plots indicate the Median of bacterial counts. E. 14 mice per group were infected i.g. with 5×10∧9 Lm LO28InlA* and survival was monitored over ten days.