Characterization of Influenza Vaccine Immunogenicity Using Influenza Antigen Microarrays
Figure 6
Influenza HA peptide reactivity correlates with age/post-vaccine neutralization titer.
(a–d) Volcano plots displaying significance of the Pearson r correlation coefficient “−log(p value Pearson r)”, corresponding to the relationship of (a) age; (b) H1N1 cPost; (c) H3N2 cPost; and (d) B cPost neutralization titer with pre- and post-vaccine reactivity to H1N1, H3N2 and B-strain peptides. The Pearson r correlation coefficient is plotted on the x-axis. Red and blue color represents positive or negative correlation, respectively, of associations with a q value determined to be less than 0.2. Gray color indicates peptide associations that were not significant. (e) Table and heatmap displaying correlation coefficient (Pearson r), p value and false discovery rate (FDR) q value of the significant peptide reactivity shown in a–d with age, H1N1 cPost, H3N2 cPost, and B cPost. Color scale represents the direction and magnitude of the Pearson r correlation coefficient. See tables S3, S4, S5, S6, for the statistical results of all comparisons.