The Small Molecule Triclabendazole Decreases the Intracellular Level of Cyclic AMP and Increases Resistance to Stress in Saccharomyces cerevisiae
Figure 2
Triclabendazole protects cells from oxidative and heat stresses.
Triclabendazole (5 μM) or vehicle was added to diluted cells in SC-glucose medium, and then cells were incubated at 30°C with shaking for 4 days. Cells were removed from the culture, serially diluted in PBS, incubated with oxidant or heated and spotted onto YPD plates. Plates were incubated at 30°C for 3 days.