Cavin1; a Regulator of Lung Function and Macrophage Phenotype
Figure 7
Gene Set Enrichment Analysis (GSEA).
GSEA performed to identify Gene Ontology (GO) terms or Biocarta, KEGG or Reactome pathways that were differentially regulated between alveolar macrophages of wild-type and Cavin1−/− mice. Of the total 14 gene sets significantly over-represented (FDR-corrected p<0.05) in Cavin1-deficient mice six of these sets, which are represented in this figure, were related to proliferative processes, such as mitosis, DNA replication, and homologous recombination, and all were coordinately down-regulated in the Cavin1−/− mice.