Rectal Transmission of Transmitted/Founder HIV-1 Is Efficiently Prevented by Topical 1% Tenofovir in BLT Humanized Mice
Figure 3
Topical tenofovir prevents rectal HIV-1JRCSF transmission in BLT mice.
Kaplan-Meier plot indicates the time to peripheral blood conversion following rectal HIV-1JRCSF exposure in BLT mice pretreated with either vehicle or topical tenofovir. Log-rank (Mantel Cox) analysis reveals a statistically significant difference in rectal HIV-1JRCSF transmission between the vehicle and topical tenofovir arms.