Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity
Figure 2
IL-33 induced alternative activation of macrophages in vitro.
BMDM from WT, STAT6−/−, or IL-4Rα−/− mice were stimulated with IL-33 (24 and 72 hours), and analyzed for the expression of arginase I (A) or YM-1 (B) by qPCR (*p<0.01 vs respective vehicle; φp<0.001 vs WT-IL-33, one-way ANOVA followed by Neuman-Keuls test). Data shown in bar graphs are the mean ± s.e.m and representative of two independent experiments with similar results.