Contribution of VH Replacement Products in Mouse Antibody Repertoire
Figure 1
Immunoglobulin VH, DH, and JH gene usages in the mouse IgH sequence repertoire.
The mouse IgH gene sequence data set containing 17,179 entries was downloaded from NCBI databases. The potential VH, DH, and JH germline gene assignments were performed using the IMGT/V-QUEST program by sending batches of sequences by the VHRFA program. Clonally redundant IgH sequences were removed if they contain identical CDR3 regions. The usages of different families of VH germline genes (A), DH genes (B), and JH (C) genes in the functional or non-functional unique IgH genes were analyzed.