A Deep Sequencing Approach to Uncover the miRNOME in the Human Heart
Figure 1
RNA content in the non-failing and failing human heart. A
, Composition of global libraries, B, non-failing, C, hypertrophic cardiomyopathy (HCM), and D, dilated cardiomyopathy (DCM). E, Correlation of number of reads with cycle threshold (Ct) values obtained by real time quantitative PCR analysis of expression of 4 different microRNAs (miR-199a, miR-199b, miR-143 and miR-145). Data pairs are represented individually, independent of the miRNA analyzed. F. Real time quantitative PCR analysis of cardiac stress markers (nppa and nppb) in DCM and HCM samples.