Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines
Figure 6
Selected region of 2D NOESY spectra of Htel/1 (a) and Htel/2 (b) complexes at 25°C in H2O, containing 25 mM KH2PO4, KCl 150 mM and EDTA 1 mM (pH 6.7).
The weakness of H8A3/H2”T2 and of H8A3/MeT2 (total disappearance in the case of Htel/1) confirms a slight distortion at these level of the sequence. The peaks A, B and C are intermolecular NOEs, (A) H1 or H4 with CH3T2, (B) H1 or H4 with H2′, H2′′ A3, (C) H3 with H2′,H2′′A3, (D) Ar with MeT2 (E) Ar with H2′,H2′′ T2 (F) Ar with H2′,H2′′ A3.