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Small Intestine Inflammation in Roquin-Mutant and Roquin-Deficient Mice

Figure 5

MLN cells from Roquin^san/san mice are proliferative and have more SLECs.

Based on Ki67 staining, (panel B) a greater proportion of OX40⁺ cells and ICOS⁺ MLN cells were proliferating T cells compared to MLN cells from (panel A) normal mice. Representative staining from 1 normal and 2 Roquin^san/san mice. Similarly, there was a greater proportion of CD44^hi CD62L^lo KLRG1⁺ SLECs present in MLN cells of (panel D) Roquin^san/san mice compared to (panel C) normal mice. Representative data from 3 normal and 3 Roquin^san/san mice.

doi: https://doi.org/10.1371/journal.pone.0056436.g005