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Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization

Figure 3

Visualization of the visibility and unique detectability results.

The activity concentration in the hot spheres was 2.4 MBq ml⁻¹ for both the images without (rows 1–3) and with background activity (rows 4–6). In the 1^st and 4^th row, the SPECT+PSF (1^st and 3^rd column) and PET+PSF+TOF (2^nd and 4^th column) slices are overlaid with the location of the visible phantom spheres (red). In rows 2, 3, 5 and 6 a background slice is overlaid with the location of false positive regions. For illustrative reasons, only the largest false positive ROIs are shown (red: 10 mm; green: 13 mm; blue: 17 mm; yellow: 22 mm; purple: 37 mm). Clustered ROIs with connecting center voxels are represented by the ROI with the highest υ_TEST-FP value.

doi: https://doi.org/10.1371/journal.pone.0055742.g003