Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism
Figure 5
Fucoidan blocks S1P-induced thermal hyperalgesia.
Intraplantar injection of A) S1P (0.3 μg) or B) the S1PR1 agonist, SEW2871 (0.3 μg), led to a time-dependent development of thermal hyperalgesia that was attenuated by pretreatment with fucoidan (40 mg/kg, i.p.). Results are expressed as mean ± SEM for 6 rats and analyzed by two-way repeated measures ANOVA with Bonferroni post hoc test where *P<0.05, **P<0.001 vs. carrageenan; † P<0.01, †† P<0.001 vs. vehicle.