The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model
Figure 6
The AMPA/NMDA ratio in the LA neurons.
(A) Sample traces showing the synaptic current at −70 and +40 mV in the saline (n = 9) and VPA (n = 12) offspring. Average AMPA/NMDA ratio in the saline and VPA offspring at the thalamic–amygdala pathway. Scale; 50 ms, 40 pA. (B) No difference was observed in the current–voltage curve of AMPA receptor-mediated EPSCs in the LA neurons from the saline and VPA offspring. A sample trace and plot of the I–V curve of AMPA-mediated EPSCs were recorded in the presence of APV (20 µM) and bicuculline (10 µM) at holding potentials of −60 mV to +20 mV in the saline (n = 7) and VPA offspring (n = 8) at the thalamic–amygdala pathway. Scale; 50 ms, 40 pA.