Chemical Memory Reactions Induced Bursting Dynamics in Gene Expression
Figure 7
Damped oscillation of the p53 module in a population of cells.
(A) Fractions of cells showing different pulse numbers of ATM activity when cells were irradiated by different gamma doses. The averaged copy numbers of p53 (B) and MDM2 (C) based on 1000 simulations. (Solid-line: gamma dose 10 Gy, dash-dot-line: 2.5 Gy, and dash-line: 0.3 Gy).