High-Mobility Group Box-1 Induces Proinflammatory Cytokines Production of Kupffer Cells through TLRs-Dependent Signaling Pathway after Burn Injury
Figure 1
HMGB1 stimulated TNF-α and IL-1β production in KCs from sham and burn rats.
KCs responded to an in vitro HMGB1 challenge with a significant and dose-dependent increase in TNF-α and IL-1β secretion. HMGB1 induced significantly greater amounts of TNF-α and IL-1β secretion in KCs from burn rats compared to those from sham animals. (A) TNF-α release by KCs from sham and burn rats. (B) IL-1β release by KCs from sham and burn rats. Results were given as mean±SEM (n = 8). & = p<0.05, && = p<0.01 vs. related sham group.