Major Facilitator Superfamily Domain-Containing Protein 2a (MFSD2A) Has Roles in Body Growth, Motor Function, and Lipid Metabolism
Figure 9
Mfsd2a KO mice develop glucose intolerance but are resistant to diet-induced obesity.
A, Growth curves for WT and KO male mice fed chow or high-fat diet (HFD) starting at 6 weeks of age (n = 4–8 per genotype). B and C, Average body weight (left), absolute adiposity (center), and relative adiposity (right) for WT (open bar) and KO (closed bar) cohorts fed B, 10 days and C, 10 weeks of HFD. D, WT and E, KO livers stained with ORO for neutral lipid following 10 weeks of HFD. F, GTT after overnight fast of WT and KO males fed HFD for 10 weeks (n = 3–4 mice per genotype, data representative of two independent experiments). Data are displayed as mean ± SEM. * p<0.05, ** p<0.01, *** p<0.001, N.S. = not significant.