Secondary Structure, a Missing Component of Sequence-Based Minimotif Definitions
Figure 2
Identification of xYxN sequences in the PDB with the same structure as Grb2 SH2 ligands.
A. A bar plot showing the distribution of centroid scores for the 46,593 xYxN structures in the PDB fit to the structure of the Grb2 SH2 peptide ligand (1JYR). The red box shows the 203 structures that match the known positive minimotifs. B. A fit of the Cα backbone traces of the 203 matched structures (green lines) to the backbone trace of the xYxN structure in 1JYR (red pipe).