Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells
Figure 1
Screening of spirooxindole derivatives for anti-tumor activity on melanoma cells.
(A) Structure of analogues SOID-1 to SOID-12 inspired by natural product Sprotryprostatin B. (B) Effect of spirooxindole derivatives on melanoma cell growth. A2058 and A375 cells were treated with a series of spirooxindole derivatives (30 µM) for 24 h, and cell viability was evaluated by MTS assay. DMSO was used as vehicle control. Data are shown as means ± SEM. Statistical significance between SOID-8 treatment and DMSO control, determined by the two-tailed Student's t test, is indicated by ***, p<0.001.