Low Dose Nicotine and Antagonism of β2 Subunit Containing Nicotinic Acetylcholine Receptors Have Similar Effects on Affective Behavior in Mice
Figure 4
Antagonism of β2*nAChRs promoted anxiolysis-like behavior in the elevated plus maze.
A) Mice receiving 0.3 mg/kg i.p. DHβE required less time to explore the end terminus of the open arms of an elevated plus maze, B) made more entries into the open arms of the maze and C) spent more time in the open arms than saline-injected mice. Data are presented as means ± SEM; *p<0.05, #p = 0.067 compared to saline controls.