Skip to main content
Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

< Back to Article

Urea Amidolyase (DUR1,2) Contributes to Virulence and Kidney Pathogenesis of Candida albicans

Figure 1

Dur1,2p function in urea metabolism and virulence.

(A). Urea uptake by WT (A72), dur1,2Δ/dur1,2Δ mutant and reconstituted C. albicans strain dur1,2Δ::DUR1,2/dur1,2Δ::DUR1,2. Radioactive uptake into 4−5×106 cells is presented after exposure to 14C urea for 5 and 15 min in the absence or presence of sodium azide. Values shown are the average of triplicate experiments ± SE. Closed bars indicate 5 min uptake, and open bars indicate 15 min uptake of radioactive urea. (B). Effect of DUR1,2 deletion on mouse mortality following intravenous infection. Survival of mice injected with WT C. albicans A72 (•), the null mutant KWN6 (▪), single copy reconstituted KWN7 (▾), fully reconstituted KWN8 (▴), and an uninfected control group of 5 mice (not shown) was assessed daily. Each infected group contained 15 mice.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0048475.g001