Liraglutide Increases FGF-21 Activity and Insulin Sensitivity in High Fat Diet and Adiponectin Knockdown Induced Insulin Resistance
Figure 2
Adiponectin knockdown aggravates HFD-induced insulin resistance.
A) Experimental design for hyperinsulinemic-euglycemic clamp studies. B) Plasma insulin levels before and during euglycaemic– hyperinsulinaemic clamping. C) Glucose infusion rate (GIR) during the clamp. D) Glucose disposal rate (GRd) before and during the insulin clamp studies. E) Hepatic glucose production before and during the clamp studies. F) Suppression of glucose production during the clamp period express as percent decrease from basal glucose production. Control, ApoE−/− mice fed with regular chow; HF, HFD-fed ApoE−/− mice treated with saline; Ad-shGFP, HFD-fed ApoE−/− mice treated with Ad-shGFP; Ad-shAcrp30, HFD-fed ApoE−/− mice treated with Ad-shAcrp30. All values are mean ± SE.