Dietary Manipulation and Social Isolation Alter Disease Progression in a Murine Model of Coronary Heart Disease
Figure 5
Effects of population density and sex on plasma cholesterol levels of Paigen diet-fed HypoE mice.
HypoE mice were housed singly (1/cage, black bars; males, n = 16, females; n = 13) or in mixed genotype groups (HypoE and one or more SRBI+/−ApoeR61h/h littermates per group, 4–5/cage, gray bars; males, n = 19, females; n = 24). Beginning at two months of age the animals were switched from a normal chow diet to the Paigen diet. After 19 days of Paigen diet feeding, plasma was harvested and total cholesterol (TC), unesterified cholesterol (UC) and UC/TC ratios were determined from the HypoE mice. Data are means ± SD. Statistically significant differences were determined by unpaired Student’s t or Mann-Whitney test.