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Cigarette Smoke Promotes Drug Resistance and Expansion of Cancer Stem Cell-Like Side Population

Figure 4

Inhibition of PI3K reduces CSC-mediated doxorubicin efflux.

(A) PI3K inhibitor LY294002 (LY) decreases doxorubicin efflux in cell lines 10B and A549. Values are derived from flow cytometric analysis of intraceulluar doxorubicin levels, and are computed relative to non-LY treated controls. (B) Western blot analysis showing the change in levels of phospho-Akt and Akt with increasing dosage of CSC. (C) Western blot analysis showing the reversal of Akt activation by treatment with LY, and the expression of ABCG2 in the presence of LY.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0047919.g004