Soluble IL-2Rα (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice
Figure 4
sCD25 acts early during Th17 development.
Purified naive CD4+ T cells from IL-17AeGFP reporter mice activated under Th17 inducing conditions in the presence of sCD25 (20 µg/ml) or anti-IL-2 (10 µg/ml) for 48 hrs and examined for levels of (A) IL-17A and (B) RORγT expression by FACS. All data are representative of at least 3 independent experiments.