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The Relative Influences of Phosphometabolites and pH on Action Potential Morphology during Myocardial Reperfusion: A Simulation Study

Figure 3

Summary of simulations.

In each simulation, the end-reperfusion targets of extracellular pH () (A) and/or ATP (B) and PCr (C) were controlled. Gray regions denote ischemic phase of simulations. In the control simulation (solid black lines), recovered toward a target during reperfusion that was equal to its preischemic value, while ATP and PCr concentrations recovered to values that were 40 and 75 percent of their preischemic concentrations, respectively. In the Dual Clamp simulation, and the concentrations of ATP and PCr were held at their end ischemic values throughout the 10 minutes of reperfusion. In the “pH” simulations, was varied during reperfusion while ATP and PCr concentrations followed their control protocols (solid black lines). In the “pH Clamp” simulation (dashed green line in (A)), was held at its end ischemic value throughout reperfusion. In the “pH 7.9” simulation (solid green line in (A)), recovered toward a value of 7.9. Conversely, in the “ATP” simulations, the recovery protocols for ATP and PCr were varied while followed its control protocol. In the “ATP Clamp” simulation (dashed red lines in (B) and (C)), the concentrations of ATP and PCr were held at their end ischemic values throughout reperfusion. In the “ATP 50” and “ATP 200” simulations (solid red lines in (B) and (C)), the concentrations of both ATP and PCr recovered to 50 and 200 percent of their targets in the control simulation, respectively. This represents only a subset of the simulations that were performed. The full simulation set is summarized in Text S1.

doi: https://doi.org/10.1371/journal.pone.0047117.g003