Mannosylated Mucin-Type Immunoglobulin Fusion Proteins Enhance Antigen-Specific Antibody and T Lymphocyte Responses
Figure 2
OVA specific IgG antibody titers.
Serum IgG antibody titers against OVA in study A (A) and B (B). Titres are given as mean +SD (n = 8–9 in study A and 8–10 in study B) and are defined as the reciprocal endpoint dilution giving an optical density at 450 nm of 3 times (A) or ≥0.2 above (B) the background value. In study A (A), the asterisk (**) indicates a significantly higher IgG titer compared to all other groups and (*) indicates a significantly higher IgG titer compared to all groups except OVA−PPM+AbISCO-100 at that time point. In study B, the asterisk (*) indicates a significantly higher IgG titer compared to all other groups. P<0.05. Serum IgG-isotype antibody titers against OVA in study A (C) and B (D). Titres are given as mean +SD (n = 8–9 in study A and 8–10 in study B) and are defined as the reciprocal endpoint dilution giving an optical density at 450 nm of 3 times (C) or ≥0.2 above (D) the background value. The asterisk (**) indicates a significantly higher IgG titer compared to all other groups. P<0.05. An (*) indicates a significantly higher IgG titer compared to all groups except the group indicated N.S. (non significant) at that time point. P<0.05.