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The Protease Degrading Sperm Histones Post-Fertilization in Sea Urchin Eggs Is a Nuclear Cathepsin L That Is Further Required for Embryo Development

Figure 2

Alignment of SpH proteases sequences (ClustalW).

The following sequences are compared: S. granularis, S. purpuratus (XP_779916.1), cephalochordate B. floridae (AAQ01138.1), G. gallus (XP_425038.2), X. laevis (NP_001087489.1), O. latipes (Medaka, gi|50251128|), M. musculus (NP_034114.1), H. sapiens L1 (NP_001903.1) and L2 (NP_001324.2, also referred as cathepsin V). The 21 encoded amino acids between the first ATG and the putative first Met of the S. granularis sequence are indicated in italic. The catalytic triad of Cys-144, His-283 and Asn-303 as well as the ERFNIN, GNFD and GCNGG motives are enframed. The theoretical cleavage site of the prodomain is indicated (<$>\raster="rg2"<$>) upstream from the peptide homologous to the N-terminal sequence of T. niger mature SpHp (underlined).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0046850.g002