The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment
Figure 1
Venn diagrams of regulated probes on the array.
The number of significantly regulated transcripts is shown in the three HIV-1 infected groups (Groups B, C, and D) as compared to uninfected controls (Group A) in three brain sectors. The criteria for significance employed a cutoff filter of ±2 fold change and p≤0.05 with the Benjamini-Hochberg correction for multiple testing comparisons using S+ArrayAnalyzer. Outer lobes represent probes regulated exclusively in one group. Regions within points of intersection represent probes regulated in more than one group. Group D (in green) contains NCI subjects with HIVE and had the most regulated genes in every brain sector. In neostriatum 91% of the probes with HIVE were upregulated. In neocortex 84% of the probes with HIVE were downregulated. Group C (yellow) contains NCI subjects without HIVE. Group B (purple) contains HIV-1-infected subjects without any NCI or HIVE. Groups B and C had few regulated probes that were delimited to neostriatum primarily. See Table 2 for the lists of regulated canonical pathways.