Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway
Figure 7
Hypothetical modes of action of actives compounds.
Four potential mechanisms of action for hit compounds to activate Keap1-Nrf2-ARE pathway. Hit compounds can disrupt binding of Keap1 to Nrf2, facilitate Keap1 ubiquitination, inactivate Nrf2 export signaling, or activate protein kinase cascades for Nrf2 phosphorylation.