Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer
Figure 1
Genome-wide views of DNA copy number alterations in Fe-NTA induced rat renal cell carcinomas (RCCs).
(A) Representative array-based CGH profiles from two RCC tumors. The red lines show log2 ratios of the estimated copy number over the inferred cancer ploidy versus the genomic position for all of the CGH microarray probes. (B) Frequency distribution of copy number aberrations across the whole rat genome. The relative frequencies of amplification (dark red), gain (tomato), loss (green yellow) and homozygous deletion (dark green) within 13 RCC tumors and two RCC cell lines are plotted at each genomic position. Two cancer-related loci, Met and Cdkn2a, which were most frequently affected by copy number aberration are indicated by the arrows.