Detection of Urinary Excreted Fungal Galactomannan-like Antigens for Diagnosis of Invasive Aspergillosis
Figure 1
MAb476 recognizes in vivo Galf antigen in a murine model of IA and localizes in the bladder of infected mice.
A,B Sandwich ELISA detection of Galf-containing antigen in BAL and lung homogenates (panel A; N = 5–6) and serum (panel B; N = 2–6) of neutropenic mice, 2 days after aerosol infection with A. fumigatus. C, Organ distribution of 99mTc-MAb476 2 days after infection; Top, control mouse: 99mTc-label localization in liver and spleen; Bottom, infected mouse: 99mTc-label localized in the bladder, representative of 2 independent experiments (N = 3 per group).