Tumor Associated Macrophage × Cancer Cell Hybrids May Acquire Cancer Stem Cell Properties in Breast Cancer
Figure 5
Tumorigenicity of hybrid xenografts in NOD/SCID mice.
Tumor formation and growth were monitored in NOD/SCID mice orthotopically injected with hybrids or parental breast cancer cell lines. Lung metastasis was also examined in NOD/SCID mice after tail-vein injection with hybrids or parent cells. A: The orthotopic tumors. B: The orthotopic tumors metastasizing to the lungs. C, D: Tumor growth curves of MCF-7 and MDA-MB-231 hybrids; data are shown as the mean ± standard error of 3 mice. E: Lung metastasis after tail vein injection. F: Representative NOD/SCID mice tumors after orthotopic injection of 5×105 cells. G: A representative images of tumors excised from each group as indicated (×200).