Shared “Core” Areas between the Pain and Other Task-Related Networks
Figure 2
Areas of spatial overlap between Pain, Memory, Tactile stimulation, Interoception, Attention, Motor execution, Emotions and Reward networks.
Upper left panel: The maps showed an increased probability of overlap between networks in the thalamus, anterior and mid-cingulate cortices, supplementary and pre-supplementary motor areas, sensorimotor, premotor, supramarginal and inferior parietal cortices. Areas with 0% probability of overlap are colored in red. A progressive increase in the probability of overlap is represented in shades of yellow. The probability map was calculated by summing the voxel value of each ALE-generated network and dividing this value by the number of networks (8). Single network maps created before the probability maps were thresholded at p<0.05, minimum cluster size k>100 mm3. Upper right panel: Conjunction analysis. We inspected pivotal areas of intersection between networks by performing a conjunction analysis of all eight maps (100% of spatial overlap). A comparison between this plot and the one presented in the middle panel of Figure 3 highlights the similarity of the results, although these were obtained with a different methodology (see text for further details). Lower panel: Meta-analytic connectivity of the network composed of the anterior insulae, the dorsal anterior cingulate cortex and the right medial dorsal thalamic nucleus. ALE maps were computed at an FDR-corrected threshold of p<0.05; minimum cluster dimension k>100 mm3 and visualized using Mricron (http://www.cabiatl.com/mricro/mricron/index.htm).