TNF-Overexpression in Borna Disease Virus-Infected Mouse Brains Triggers Inflammatory Reaction and Epileptic Seizures
Figure 3
Transgenic TNF (TNFtg) mRNA values in different brain areas in TNF-transgenic and wild-type mice.
TNFtg mRNA was present only in the transgenic animals. TNFtg mRNA copy numbers were significantly higher in the cerebral cortex, hippocampus and striatum when compared to the cerebellum in Tg/– and Tg/Tg animals regardless of BDV-infection. No TNFtg mRNA was detected in the wild-type mice in any brain area. dpi: days post infection, –/–: non-transgenic mice, Tg/–: heterozygous transgenic mice, Tg/Tg: homozygous transgenic mice, geometric mean, bar: distribution factor