Correlation between Multi-Drug Resistance-Associated Membrane Transport in Clonal Cancer Cells and the Cell Cycle Phase
Figure 3
Simulation of fluorescein efflux kinetics assuming Michaelis-type process in model single cells and cell population.
Simulation of single-cell and population kinetics of a Michaelis-Menten-type reaction. A, variation of Vmax in a population of 10 individual cell cells. B, simulated single-cell and averaged population kinetics, simulation performed using the integrated Michaelis-Menten equation: Vmaxt = ([S]0 – [S]) + KM ln([S]0/([S]0 – [S])).