Proteomic and Systems Biology Analysis of Monocytes Exposed to Securinine, a GABAA Receptor Antagonist and Immune Adjuvant
Figure 4
Schematic diagram of proposed functions of Hsp70 in Securinine stimulated monocytes, based on the literature.
Proposed activities include increased monocyte maturation, inhibition of apoptosis, intracellular signaling (Ca2+, p38, NF-κB), and extracellular signaling (danger signal).